Philippe Gros Genetics

Cloned the Nramp gene and the mdr gene

The Story

Working with Emile Skamene (McGill Centre for the Study of Host Resistance), Erwin Schurr, and Ken Morgan (Epidemiology and Biostatistics), Philippe Gros cloned the bcg gene in mice and then identified the equivalent gene in humans, called Nramp. Mutations in the Nramp gene create vulnerability to several infectious diseases, including tuberculosis, leprosy, salmonellosis (typhoid fever) and leishmaniasis. Gros and his team also researched the mechanism by which this gene controls susceptibility to these infectious diseases. Gros’s other major breakthrough is the cloning of the mdr (multidrug resistance) gene family, which controls resistance to drugs used in anticancer chemotherapy. Gros is the recipient of the first Michael Smith Award of Excellence and an MRC Senior Scientist Award in 1995 (both awards are from the Medical Research Council of Canada).

Sources: McGill Reporter, March 3, 1995; MRC Communiqué

Image: McGill

 

The Person

Title
Biochemist and director of biochemistry lab, McIntyre Medical Sciences Building
Office
McGill University, Montreal, Quebec
Status
Working
Degrees
  • PhD, McGill University, 1983
Awards
  • Fellow of the Royal Society of Canada
Last Updated
October 15, 2001
Popularity
28118

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